# US 10,368,770 B2 · Neural event process > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,368,770 B2 - Document ID: US10368770B2 - Status: Granted - Kind: B2 - Application number: 11/661,622 - Filed: 2005-09-01 - Published: 2008-07-10 - Granted: 2019-08-06 - Earliest claimed: 2004-09-01 - Assignees: Monash University - Applicants: Brian John Lithgow - Inventors: Brian John Lithgow - Web page: https://patentgrep.com/patent/US10368770B2 ## CPC - A61B 5/374: Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves - A61B 5/165: {Evaluating the state of mind, e.g. depression, anxiety} - A61B 5/37: Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG] - A61B 5/38: Acoustic or auditory stimuli - A61B 5/384: Recording apparatus or displays specially adapted therefor - A61B 5/4082: {Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette} - A61B 5/6814: {Head} - A61B 5/7239: {using differentiation including higher order derivatives} - A61B 5/40: {Detecting, measuring or recording for evaluating the nervous system (for sleep A61B5/4806; for anaesthesia A61B5/4821; for pain A61B5/4824)} - A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A neural event process, including receiving a neural response signal, decomposing the signal using at least one wavelet, differentiating phase data of the wavelets and the response signal to determine maxima and minima of the phase data and the signal, and processing the maxima and minima to determine peaks representing neural events. ## Claims ### Claim 1 A neural event process, executed by a computer device, including: receiving an electrovestibulography (EVestG) signal associated with a person; decomposing said signal using wavelets; obtaining derivatives of phase data of said wavelets using the computer device; obtaining derivatives of said response signal; determining maxima and minima of said phase data using the derivatives of said phase data; determining maxima and minima of said response signal using the derivatives of said response signal; processing said maxima and minima of said phase data and said maxima and minima of said response signal with the computing device to extract timing information to determine peaks representing neural events; wherein said obtaining derivatives of phase data includes generating first and second derivatives of said phase data produced by said decomposing, and said maxima and minima of said phase data represent rate of change of phase of scales of said wavelets; and wherein said maxima and minima of said phase data and said response signal are used to generate data indicating whether said person has a central nervous system disorder. ### Claim 2 (depends on 1) A neural event process as claimed in claim 1, wherein said decomposing is performed using said wavelets with a bandwidth factor less than one. ### Claim 3 (depends on 2) A neural event process as claimed in claim 2, wherein said wavelets have centre frequencies across a frequency spectrum of said signal. ### Claim 4 (depends on 1) A neural event process as claimed in claim 1, wherein said obtaining derivatives of said response signal includes generating first and second derivatives of said response signal to produce said maxima and minima of said response signal, and said processing includes correlating said maxima and minima of said phase data and said maxima and minima of said response signal based on time data for said maxima and minima of said response signal. ### Claim 5 (depends on 4) A neural event process as claimed in claim 4, wherein said processing includes eliminating false peaks by applying threshold data to said maxima and minima of said phase data and said response signal. ### Claim 6 (depends on 5) A neural event process as claimed in claim 5, wherein said correlating includes linking said maxima of said phase data across said scales and across a time band to eliminate false peaks. ### Claim 7 (depends on 6) A neural event process as claimed in claim 6, wherein said processing includes applying predetermined latency ranges for said peaks to said maxima and minima of said phase data to determine said peaks. ### Claim 8 (depends on 7) A neural event process as claimed in claim 7, wherein said receiving includes filtering and sampling said response signal for said decomposing, differentiating and processing. ### Claim 9 (depends on 2) A neural event process as claimed in claim 2, wherein said bandwidth factor is between 0.05 and 0.4. ### Claim 10 (depends on 9) A neural event process as claimed in claim 9, wherein said bandwidth factor is 0.1 for low frequency scales and 0.4 for other scales. ### Claim 11 (depends on 9) A neural event process as claimed in claim 9, wherein said bandwidth factor is 0.05 for the lowest frequency scale. ### Claim 12 (depends on 8) A neural event process as claimed in claim 8, including removing at least one artefact from said response signal. ### Claim 13 (depends on 1) A neural event process as claimed in claim 1, wherein said neural events are represented by summating potential (Sp) and action potential (Ap) markers corresponding to said peaks. ### Claim 14 (depends on 1) A neural event process as claimed in claim 1, wherein said maxima and minima of said phase data and said signal are compared to generate a summating potential (Sp)/action potential (Ap) plot. ### Claim 15 (depends on 1) A neural event process as claimed in claim 1, wherein said EVestG signal is produced by a EVestG system in response to a head tilt of the person. ### Claim 16 (depends on 15) A neural event process as claimed in claim 15, wherein said maxima and minima of said phase data and said response signal are used to generate data indicating a response by said person to medication for a central nervous system disorder. ### Claim 17 (depends on 15) A neural event process as claimed in claim 15, wherein said maxima and minima of said phase data and said response signal are used to generate data indicating whether said person has Meniere's disease. ### Claim 18 (depends on 15) A neural event process as claimed in claim 15, wherein said maxima and minima of said phase data and said response signal are used to generate data indicating a response by said person to medication for Meniere's disease. ### Claim 19 (depends on 15) A neural event process as claimed in claim 15, wherein said maxima and minima of said phase data and said response signal are used to generate data indicating whether said person has Parkinson's disease. ### Claim 20 (depends on 15) A neural event process as claimed in claim 15, wherein said maxima and minima of said phase data and said response signal are used to generate data indicating a response by said person to medication for Parkinson's disease. ### Claim 21 (depends on 15) A neural event process as claimed in claim 15, wherein said maxima and minima of said phase data and said response signal are used to generate data indicating whether said person has depression. ### Claim 22 (depends on 15) A neural event process as claimed in claim 15, wherein said maxima and minima of said phase data and said response signal are used to generate data indicating a response by said person to medication for depression. ### Claim 23 (depends on 1) A neural event process as claimed in claim 1, wherein said maxima and minima of said phase data and said response signal represents a response obtained directly from the vestibular system of the person. ### Claim 24 (depends on 1) A neural event process as claimed in claim 1, wherein said maxima and minima of said phase data and said response signal represent components of the vestibular system. ### Claim 25 (depends on 1) A neural event process as claimed in claim 1, wherein said maxima and minima of said phase data and said response signal represents a response obtained directly from auditory nuclei and subnuclei of the ear of the person. ### Claim 26 A neural event process, executed by a computer device, including: receiving a neural response signal associated with a person and produced by an electrocochleography system; decomposing said signal using at least one wavelet representing a centre frequency having a low frequency in the spectrum of said signal, said wavelet having a bandwidth factor greater than or equal to 0.05 and less than 1; obtaining derivatives of phase data of said wavelet using the computer device; obtaining derivatives of said response signal; determining maxima and minima of said phase data using the derivatives of said phase data; determining maxima and minima of said response signal using the derivatives of said response signal; and processing said maxima and minima of said phase data and said maxima and minima of said response signal to extract timing information to determine summating potential (Sp) and action potential (Ap) data; wherein said obtaining derivatives of phase data includes generating first and second derivatives of said phase data produced by said decomposing, and said maxima and minima of said phase data represent rate of change of phase of scales of said wavelets; and wherein said maxima and minima of said phase data and said response signal are used to generate data indicating whether said person has a central nervous system disorder. ### Claim 27 A neural event process, executed by a computer device, including: receiving an auditory brain stem response (ABR) signal associated with a person and produced by an ABR system; decomposing said signal using at least one wavelet representing a centre frequency having a low frequency in the spectrum of said signal, said wavelet having a small bandwidth factor; obtaining derivatives of phase data of said wavelet using the computer device; obtaining derivatives of said response signal; determining maxima and minima of said phase data using the derivatives of said phase data; determining maxima and minima of said response signal using the derivatives of said response signal; and processing said maxima and minima of said phase data and said maxima and minima of said response signal to extract timing information to determine peaks representing neural events; wherein said obtaining derivatives of phase data includes generating first and second derivatives of said phase data produced by said decomposing, and said maxima and minima of said phase data represent rate of change of phase of scales of said wavelets; and wherein said maxima and minima of said phase data and said response signal are used to generate data indicating whether said person has a central nervous system disorder. ### Claim 28 (depends on 24) A neural event process as claimed in claim 24, wherein said neural events represent auditory nuclei and subnuclei. ### Claim 29 (depends on 27) A neural event response process as claimed in claim 27, wherein said bandwidth factor is 0.05 for the lowest frequency scale. ### Claim 30 (depends on 1) A computer readable storage device storing computer program code, which when executed by a processing device causes the processing device to perform the process as claimed in claim 1.