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US 10,364,261 B2Granted
DNA alkylating agents
AssigneeObi Pharma, Inc.
InventorsJian-Xin Duan, Yeyu Cao, Xiaohong Cai, Hailong Jiao, Jing Yuan Ma, Mark Matteucci
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds of formula I: wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.
Claims11
A compound of formula I:
- or a pharmaceutically acceptable salt, or a solvate of each thereof, wherein
- X10 is O, S, SO, or SO2;
- A is C6-C10 aryl, 5-15 membered heteroaryl, or —N═CR1R2;
- each R1 and R2 independently is hydrogen, -13 CN, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl, ether, —CONR13R14, or —NR13COR14;
- each X and Z independently is hydrogen or C1-C6 alkyl;
- Y is hydrogen, halo, or C1-C6 alkyl;
- R is hydrogen or C1-C6 alkyl;
- each R13 and R14 independently is hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl, or ether;
- T is OP(Z1)(NHCH2CH2Cl)2, OP(Z1)(NHCH2CH2Br)2, OP(Z1)(NH2)(N(CH2CH2X1)2), OP(Z1)(N(CH2)2)2, or OP(Z1)(N(CH2CH2C1)2)2, wherein Z1 is O or S, and X1 is C1, Br, or OMs;
- and
- wherein the alkyl, cycloalkyl, aryl, heterocycle, heteroaryl, ether groups are optionally substituted.
8 more elements
Dependencies are inferred from the claim text.