Pyridazinone compounds and uses thereof

A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

• wherein:
• G1 is selected from the group consisting of
• and R5;
• G2 is hydrogen, halogen, —CN, an optionally substituted C1-6 alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, —CH2OH, —CH(Y1)(OH) or —C(O)Y1;
• G3 is selected from the group consisting of hydrogen, —C(O)Y2, —C(O)O—Y2, —(CH2)—OC(O)Y2, —(CH2)—OC(O)OY2, —(CHCH3)—OC(O)Y2 and —(CHCH3)—OC(O)OY2;
• Y1 and Y2 are independently an optionally substituted C1-6 alkyl or an optionally substituted aryl;
• R1 is selected from the group consisting of OR6, NH2, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted mono-substituted amine, an optionally substituted di-substituted amine, an optionally substituted heterocyclyl, an optionally substituted N-sulfonamido and an optionally substituted alkoxyamine,
• or R1 is R10;
• R2 is hydrogen, C1-6 alkyl, an optionally substituted C3-6 cycloalkyl, an optionally substituted aryl, an optionally substituted aryl(C1-6 alkyl) or an optionally substituted C-amido;
• R3 is hydrogen or C1-6 alkyl;
• or R2 and R3 are taken together with the carbon to which they are attached to form an optionally substituted C3-6 cycloalkyl or an optionally substituted 5 to 6 membered heterocyclyl,
• or R2 and R3 are taken together to form ═O;
• R4 is selected from the group consisting of an optionally substituted aryl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl;
• or R4 is A1RA4RB4, wherein A1 is CH or N;
• and RA4 and RB4 are each independently an optionally substituted phenyl;
• R5 is selected from the group consisting of an optionally substituted aryl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl;
• R6 is selected from the group consisting of hydrogen, C1-6 alkyl, —C(O)R7 and —C(O)NR8R9;
• R7 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heterocyclyl, aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl) and heterocyclyl(C1-6 alkyl);
• and
• R8 and R9 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heterocyclyl, aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl) and heterocyclyl(C1-6 alkyl);
• or R8 and R9 are taken together with the nitrogen to which they are attached to form an optionally substituted heterocyclyl;
• wherein when R1 is R10, then the compound of Formula (I) has the structure of Formula (Ih) or (Ij),
• wherein the ring containing R10, L1, and R4 is an 11- to 20-membered ring, and the ring containing R10, L1, and R5 is an 11- to 20-membered ring;
• R10 is optionally substituted —CH2—, optionally substituted —CH═CH—, O (oxygen), S (sulfur) or NR11;
• R11 is hydrogen or C1-6 alkyl;
• L1 is -L2- or -L3-L4-L5-;
• L2 is selected from the group consisting of an optionally substituted alkylene, an optionally substituted alkenylene, an optionally substituted heteroalkylene and an optionally substituted heteroalkenylene,
• L3 is an optionally substituted C1-6 alkylene,
• L4 is an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl, O (oxygen), S (sulfur) or NR11;
• and
• L5 is an optionally substituted C1.6 alkylene or an optionally substituted heteroalkylene, and
• Z1 and Z2 are independently 0, 1, 2, 3 or 4.