Pharmaceutical composition
AssigneesThe South African Nuclear Energy Corporation Limited, North-West University
InventorsAnne Frederica Grobler, Jan Rijn Zeevaart
Life of this patent
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Abstract
This invention relates to a pharmaceutical composition for parenteral or oral administration containing a radioactive compound which can be used diagnostically or therapeutically. The composition comprises a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids, and the radioactive compound.
Claims6
A method of administering a radiolabelled pharmaceutical compound to a subject in need thereof, the method including the steps of:
- providing a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, ricinoleic acid, eicosapentaenoic acid [C20 5ω3], and decosahexaenoic acid [C22 6ω3] and derivatives thereof selected from the group consisting of the C1 to C6 alkyl esters thereof, the glycerol-polyethylene glycol esters thereof, and a reaction product of hydrogenated and unhydrogenated natural oils comprising ricinoleic acid based oils with ethylene oxide, mixed with a composition containing a radiolabelled pharmaceutical compound comprising a radioactive compound labelled to a pharmaceutical compound wherein the radioactive compound is selected from 99mTc, 188Re, 186Re, 153Sm, 166Ho, 90Sr, 89Sr, 67Ga, 68Ga, 111In, 183Gd, 59Fe, 225Ac, 212Bi, 211At, 211At, 45Ti, 60Cu, 61Cu, 67Cu, 64Cu, 62Cu, 195mPt, 191mPt, 193mPt, 117mSn, 103Pd, 103mRh, 89Zr, 177Lu, 223Ra, 224Ra, 32P and 33P, and administering the mixture to the subject orally in a diagnostic or therapeutic method of treatment, wherein the radiolabelled pharmaceutical compound is absorbed through an intestinal tract of the subject and is transported to a required location in the body after administration where the radiolabelled pharmaceutical compound has a diagnostic or therapeutic effect.
Dependencies are inferred from the claim text.