Pharmaceutical formulation for use in the treatment and/or prevention of restenosis

A method of treatment of restenosis after open surgical revascularization in a subject in need thereof, said method comprising administering by the perivascular route a pharmaceutical formulation consisting in a gel phase comprising

• i) at least one rapidly delivered compound effective on the acute inflammatory phase of the early stage of restenosis development comprising a statin, and
• ii) a sustained release formulation comprising a statin effective on later phases of restenosis development, wherein the sustained release formulation is in the form of microspheres or nanospheres.