Mutant host cells for the production of 3-hydroxypropionic acid
AssigneeNovozymes A/S
InventorsJanice Frias, Guillaume Barbier
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Abstract
Provided herein are recombinant host cells having an active 3-Hydroxypropionic Acid (3-HP) pathway wherein the host cells comprise a disruption to an endogenous gene that encodes for a pyruvate reductase. Also described are methods of making the host cells, and methods using the cells to produce 3-HP and derivatives of 3-HP (e.g., acrylic acid).
Claims18
A recombinant yeast cell, wherein the recombinant yeast cell belongs to the genus Issatchenkia, wherein the recombinant yeast cell comprises (1) an active 3-hydroxypropionic acid (3-HP) pathway capable of producing 3-HP and (2) a disruption to an endogenous gene that encodes a pyruvate reductase, and wherein the amino acid sequence of the pyruvate reductase has at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 205.
Dependencies are inferred from the claim text.