Method of producing emulsions

A method of producing droplets comprising:

• a) providing a device comprising:
• i) a first channel having a first proximal end, a first distal end, a first depth, and a first width, the first channel comprising a first liquid;
• ii) a second channel having a second proximal end, a second distal end, a second depth, and a second width;
• wherein the second channel intersects the first channel between the first proximal end and the first distal end, the second channel comprising a third liquid;
• iii) a droplet formation region in fluid communication with the first distal end of the first channel, wherein the droplet formation region has a width or depth greater than the first width or first depth and the droplet formation region comprises a second liquid;
• and
• iv) a collection region in fluid communication with the droplet formation region and that collects droplets formed in the droplet formation region;
• wherein the first liquid is immiscible with the second liquid, wherein the first or third liquid comprises one or more particles and wherein the device is capable of forming droplets with the second liquid flowing in response to displacement by the droplets being formed;
• b) flowing the first liquid from the first channel and the third liquid from the second channel to the intersection to combine the first and third liquids;
• c) flowing the combined first and third liquids to the droplet formation region to produce droplets of the first liquid, third liquid, and one or more particles dispersed in the second liquid;
• d) transporting the droplets to the collection region;
• and
• e) collecting the droplets in the collection region.