Method of pre-treating an adsorbent for a chromatographic separation
AssigneeBwxt Itg Canada, Inc.
InventorSteve Oelsner
Life of this patent
Estimating the term…
Abstract
A method of treating an adsorbent for a chromatographic separation. The method involves sonicating particles of an inorganic metal oxide having fragile edges in the absence of any alkylating or acylating agent to form smoothened particles of the inorganic metal oxide and washing the smoothened particles of the inorganic metal oxide to remove fine particulate matter to produce a treated adsorbent. The treated adsorbent can be used in a method of isolating a daughter radioisotope from a daughter radioisotope that is produced from the parent radioisotope by radioactive decay.
Claims22
A method of producing a treated chromatographic separation adsorbent, comprising:
- crystallizing titanium oxide or tin oxide in the presence of a base to form a crystalline metal oxide;
- drying the crystalline metal oxide to form a chromatographic separation adsorbent;
- sonicating the chromatographic separation adsorbent, in the absence of any alkylating or acylating agent to form sonicated particles of the crystalline metal oxide and fine particulate matter of the crystalline metal oxide;
- washing the sonicated particles of the crystalline metal oxide to remove the fine particulate matter of the crystalline metal oxide to produce a washed, treated chromatographic separation adsorbent;
- and
- drying the washed, treated chromatographic separation adsorbent, thereby producing the treated chromatographic separation adsorbent.
A method of isolating a compound of interest from a crude sample, comprising:
- crystallizing titanium oxide or tin oxide in the presence of a base to form a crystalline metal oxide;
- drying the crystalline metal oxide to form a chromatographic separation adsorbent;
- sonicating the chromatographic separation adsorbent in the absence of any alkylating or acylating agent to form sonicated particles of the crystalline metal oxide and fine particulate matter of the crystalline metal oxide;
- washing the sonicated particles of the crystalline metal oxide to remove the fine particulate matter of the crystalline metal oxide, to produce a washed, treated chromatographic separation adsorbent;
- drying the washed, treated chromatographic separation adsorbent, thereby producing a treated chromatographic separation adsorbent that reduces plugging of a filtration membrane in a chromatographic column;
- and
- using the treated chromatographic separation adsorbent in the chromatographic column to isolate the compound of interest.
Dependencies are inferred from the claim text.