Methods for photodynamic therapy
AssigneeDUSA Pharmaceuticals, Inc.
InventorsScott Lundahl, Michael Guttadauro
Life of this patent
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Abstract
A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
Claims10
A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy, the method comprising:
- topically applying ALA to a treatment area to be treated with photodynamic therapy;
- after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area;
- and
- removing the low density polyethylene barrier within 3 hours and then applying light to the treatment area.
A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy, the method comprising:
- topically applying ALA to a treatment area to be treated with photodynamic therapy;
- and
- after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area,
- wherein the treatment area is located on a hand or a forearm.
A method of using 5-aminolevulinic acid (ALA) and a low density polyethylene barrier, comprising:
- contacting a treatment site with a composition comprising the ALA so as to wet the treatment site;
- following wetting of the treatment site, covering the wetted treatment site with the low density polyethylene barrier;
- removing the low density polyethylene barrier so as to expose the treatment site;
- and
- illuminating the exposed treatment site with an illuminator so as to deliver a 10 J/cm2 dose of blue light.
Dependencies are inferred from the claim text.