# US 10,357,529 B2 · Natural formulation for treating hangover

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- Number: US 10,357,529 B2
- Document ID: US10357529B2
- Status: Granted
- Kind: B2
- Application number: 15/345,143
- Filed: 2016-11-07
- Published: 2018-05-10
- Granted: 2019-07-23
- Earliest claimed: 2016-11-07
- Assignees: Rvrs, LLC
- Applicants: Rvrs, LLC
- Inventors: Nader George Mikhail
- Web page: https://patentgrep.com/patent/US10357529B2

## CPC

- A61K 36/82: Theaceae (Tea family), e.g. camellia
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K 31/01: Hydrocarbons
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/07: Retinol compounds, e.g. vitamin A (retinoic acids A61K31/203)
- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/164: of a carboxylic acid with an aminoalcohol, e.g. ceramides
- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 31/4188: condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A61K 31/4415: Pyridoxine, i.e. Vitamin B6 (pyridoxal phosphate A61K31/675)
- A61K 31/455: Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A61K 31/51: Thiamines, e.g. vitamin B1
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 31/525: Isoalloxazines, e.g. riboflavins, vitamin B2
- A61K 31/675: having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A61K 31/714: Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
- A61K 31/718: Starch or degraded starch, e.g. amylose, amylopectin
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 33/08: Oxides; Hydroxides
- A61K 33/30: Zinc; Compounds thereof
- A61K 33/44: Elemental carbon, e.g. charcoal, carbon black
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 36/33: Cactaceae (Cactus family), e.g. pricklypear or Cereus
- A61K 36/72: Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K 36/9068: Zingiber, e.g. garden ginger
- A61K 38/063: {Glutathione}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Compositions and methods for treating and/or preventing hangover are disclosed. In certain embodiments, the compositions include at least one B vitamin, activated charcoal, magnesium, and at least one herbal extract.

## Claims

### Claim 1

A composition for treating and/or preventing a hangover, the composition comprising the following ingredients;
an effective amount of milk thistle, wherein the effective amount of milk thistle is in a range of about 100 mg to about 2000 mg per unit dose;
an effective amount of a mineral, selected from magnesium or zinc, wherein the effective amount of the mineral is in a range of about 1 mg to about 500 mg per unit dose;
an effective amount of activated charcoal, wherein the effective amount of activated charcoal is in a range of about 1 mg to about 1000 mg per unit dose;
an effective amount of at least one B vitamin selected from the group consisting of B1, B2, B6 and B12, wherein the effective amount of the at least one B vitamin is in a range of about 0.01 μg to about 100 mg per unit dose; and
an effective amount of N-Acetyl-L Cysteine, wherein the effective amount of N-Acetyl-L Cysteine is in a range of about 50 mg to about 500 mg per unit dose;
wherein the effective amounts of the ingredients are sufficient in combination to treat and/or prevent the hangover.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the composition is an oral supplement.

### Claim 3 (depends on 2)

The composition of claim 2, wherein the oral supplement is a capsule or a tablet or a powder.

### Claim 4 (depends on 1)

A method for treating and/or preventing a hangover in a subject in need thereof, the method comprising providing to the subject the composition of claim 1.

### Claim 5 (depends on 4)

The method of claim 4, wherein the composition is provided in a form of a powder that is dissolved in a liquid for oral administration.

### Claim 6 (depends on 5)

The method of claim 5, wherein administering comprises orally administering one, two, three or four doses per day.

### Claim 7

A composition for treating and/or preventing a hangover, wherein the composition is in a powder form and comprises the following ingredients:
milk thistle in an amount of about 100 mg to about 2000 mg per unit dose;
magnesium oxide in an amount of about 10 mg to about 1000 mg per unit dose;
zinc oxide in an amount of about 1 mg to about 100 mg per unit dose;
ginger root extract in an amount of about 50 mg to about 1000 mg per unit dose;
prickly pear fruit concentrate in an amount of about 50 mg to about 1000 mg per unit dose;
hovenia dulcis fruit extract in an amount of about 10 mg to about 1000 mg per unit dose;
niacin in an amount of about 1 mg to about 100 mg per unit dose;
thiamine HCl in an amount of about 0.1 mg to about 1 mg per unit dose;
riboflavin in an amount of about 0.1 mg to about 1 mg per unit dose;
pyridoxine HCl in an amount of about 0.1 mg to about 10 mg per unit dose;
cyanocobalamin in an amount of about 0.1 mg to about 1 mg per unit dose;
biotin in an amount of about 10 mcg to about 500 mcg per unit dose;
folic acid in an amount of about 0.1 mcg to about 100 mcg per unit dose;
pantothenic acid in an amount of about 0.5 mg to about 50 mg per unit dose;
N-Acetyl-L Cysteine in an amount of about 50 mg to about 500 mg per unit dose;
activated charcoal in an amount of about 50 mg to about 500 mg per unit dose;
L-glutathione in an amount of about 5 mg to about 100 mg per unit dose; and green tea leaf extract in an amount of about 10 mg to about 500 mg per unit dose.