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US 10,351,604 B2Granted
Broad-spectrum anti-infective peptides
AssigneeNanyang Technological University
InventorsNam-Joon Cho, Joshua Alexander Jackman
Life of this patent
Estimating the term…
Abstract
Provided herein are anti-infective peptides and uses thereof. Such anti-infective peptides are useful against bacteria and viruses. Also provided herein are compositions comprising said anti-infective peptides.
Claims24
A peptide of 16 to 26 amino acid residues in length comprising the following amino acid sequence:
- X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is S, G or A;
- X2 is S or G;
- X3 is V or I, X4 is W or L;
- X5 is W, K, A or L;
- and X6 is W, K, L or A (SEQ ID NO:12).
2 more elements
A peptide of 16 to 26 amino acid residues in length comprising the following amino acid sequence:
- (a) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is W, F, Y or H;
- and X6 is W, F, Y or H (SEQ ID NO:27);
- (b) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is W, F, Y or H;
- and X6 is K, Y, R, H, N, Q, S, or T (SEQ ID NO:28);
- (c) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is W, F, Y or H;
- and X6 is A, C, G, P, S, I, L, V or T (SEQ ID NO:29);
- (d) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is K, Y, R, H, N, Q, S, or T;
- and X6 is W, F, Y or H (SEQ ID NO:30);
- (e) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is K, Y, R, H, N, Q, S, or T;
- and X6 is K, Y, R, H, N, Q, S, or T (SEQ ID NO:31);
- (f) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is K, Y, R, H, N, Q, S, or T;
- and X6 is A, C, G, P, S, I, L, V or T (SEQ ID NO:32);
- (g) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is A, C, G, P, S, I, L, V or T;
- and X6 is W, F, Y or H (SEQ ID NO:33);
- (h) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is A, C, G, P, S, I, L, V or T;
- and X6 is K, Y, R, H, N, Q, S, or T (SEQ ID NO:34);
- (i) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is A, C, G, P, S, T;
- X2 is A, C, G, P, S, T;
- X3 is A, I, L, P or V;
- X4 is W, F, Y, H, A, I, L, P or V;
- X5 is A, C, G, P, S, I, L, V or T;
- and X6 is A, C, G, P, S, I, L, V or T (SEQ ID NO:35);
- (j) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is G, P, or A;
- X2 is G, P, or A;
- X3 is V, I, L or M;
- X4 is W, F, Y or H;
- X5 is W, Y, or F;
- X6 is K, R, Q, E or N (SEQ ID NO:36);
- (k) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is S, T, A or Q;
- X2 is G, P, or A;
- X3 is V, I, L or M;
- X4 is W, F, Y or H;
- X5 is W, Y, or F;
- and X6 is K, R, Q, E or N (SEQ ID NO:37);
- (l) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is G, P, or A;
- X2 is G, P, or A;
- X3 is V, I, L or M;
- X4 is W, F, Y or H;
- X5 is K, R, Q, E or N;
- and X6 is W, Y, or F (SEQ ID NO:38);
- (m) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is S, T, A or Q;
- X2 is G, P, or A;
- and X3 is V, I, L or M;
- X4 is W, F, Y or H;
- X5 is K, R, Q, E or N;
- and X6 is W, Y, or F (SEQ ID NO:39);
- (n) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is S, T, A or Q;
- X2 is G, P, or A;
- X3 is V, I, L or M;
- X4 is W, F, Y or H;
- X5 is A, S, G or T;
- and X6 is W, Y, or F (SEQ ID NO:40);
- or
- (o) X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is G, P, or A;
- X2 is G, P, or A;
- X3 is V, I, L or M;
- X4 is W, F, Y or H;
- X5 is A, S, G or T;
- and X6v W, Y, or F (SEQ ID NO:18).
88 more elements
A pegylated peptide comprising the following structure:
- NH2-PEG12-Amide-PEG12-peptide, wherein the peptide is 16 to 26 amino acid residues in length and comprises the amino acid sequence:
- X1X2SWLRDX3X4TX5LQSX6L, wherein X1 is S, G or A;
- X2 is S or G;
- X3 is V or I, X4 is W or L;
- X5 is W, K, A or L;
- and X6 is W, K, L or A (SEQ ID NO:12).
3 more elements
Dependencies are inferred from the claim text.