Ether analogues of galiellalactone

A compound according to formula (I)

• wherein
• R1 and R1′ are independently selected from the group consisting of H, C1-5 alkyl, C1-5 fluoroalkyl, halo, cyano, nitro, —OH, OC1-5 alkyl, C1-5 alkyleneOH, C1-5 alkyleneOC1-5 alkyl, C3-8 non-aromatic carbocycle, OC1-5 fluoroalkyl, C1-3 alkyleneOC1-5 fluoroalkyl, OC(O)C1-5 alkyl, C1-3 alkyleneOC(O)C1-5 alkyl, OC2-3 alkyleneNH2, OC2-3 alkyleneNH(C1-5 alkyl), OC2-3 alkyleneN(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, —NH2, —NH(C1-5 alkyl), C1-3 alkyleneNH2, C1-3 alkyleneNH(C1-5 alkyl), —N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, C1-3 alkyleneN(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, NHC(O)C1-5 alkyl, N(C1-5 alkyl)C(O)C1-5 alkyl, C1-3 alkyleneNHC(O)C1-5 alkyl, C1-3 alkyleneN(C1-5 alkyl)C(O)C1-5 alkyl,
• NHaryl, C1-3 alkyleneNHaryl, wherein the aryl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of C1-5 alkyl, C1-5 fluoroalkyl, halo, —OH, OC1-5 alkyl, C1-5 alkyleneOH, C1-5 alkyleneOC1-5 alkyl, nitro, cyano, NH2, NH(C1-5 alkyl), and N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different,
• aryl, C1-3 alkylene-aryl, wherein the aryl is unsubstituted or substituted with one or several substituents independently selected from the group consisting of C1-5 alkyl, C1-5 fluoroalkyl, halo, —OH, OC1-5 alkyl, C1-5 alkyleneOH, C1-5 alkyleneOC1-5 alkyl, nitro, cyano, —NH2, —NH(C1-5 alkyl), and N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different,
• —SH, —SC1-5 alkyl, C1-5 alkylene-SH, C1-5 alkylene-SC1-5 alkyl, SC1-5 fluoroalkyl, C1-5 alkyleneSC1-5 fluoroalkyl, SO2C1-5 alkyl, C1-5 alkylene-SO2C1-5 alkyl, SO2C1-5 fluoroalkyl, C1-5 alkylene-SO2C1-5 fluoroalkyl, SO2NH2, SO2NH(C1-5 alkyl), SO2N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, C1-5 alkyleneSO2NH2, C1-5 alkyleneSO2NH(C1-5 alkyl), C1-5 alkyleneSO2N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different,
• SO2NHaryl, C1-5 alkyleneSO2NHaryl, wherein the aryl is unsubstituted or substituted with a one or several substituents independently selected from the group consisting of C1-5 alkyl, C1-5 fluoroalkyl, halo, —OH, OC1-5 alkyl, C1-5 alkyleneOH, C1-5 alkyleneOC1-5 alkyl, nitro, cyano, —NH2, —NH(C1-5 alkyl), and N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different,
• SO2N(C1-5 alkyl)aryl, and C1-5 alkyleneSO2N(C1-5 alkyl)aryl, wherein the aryl is unsubstituted or substituted with a one or several substituents independently selected from the group consisting of C1-5 alkyl, C1-5 fluoroalkyl, halo, —OH, OC1-5 alkyl, C1-5 alkyleneOH, C1-5 alkyleneOC1-5 alkyl, nitro, cyano, —NH2, —NH(C1-5 alkyl), and N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different;
• R2, R2′, R3, and R3′ are each independently selected from the group consisting of H, halo, —OH, C1-5 alkyl, and C1-5 fluoroalkyl;
• R4 and R4′ are independently selected from the group consisting of H, C1-5 alkyl, aryl, and CH2aryl;
• A is selected from the group consisting of a bond, C1-5 alkylene or NR10;
• R10 is H or C1-C3 alkyl;
• Cy1 is pyridinyl;
• R5 is independently selected from the group consisting of C1-8 alkyl, C1-5 haloalkyl, halo, cyano, —CH2-cyano, —OH, OC1-5 alkyl, C1-8 alkyleneOC1-5 alkyl, O-aryl, C1-8 alkylene-O-aryl, —SH, SC1-5 alkyl, SO2H, SO2C1-5 alkyl, C1-3 alkyleneSO2H, C1-3 alkyleneSO2C1-5 alkyl, OC1-3 fluroroalkyl, C1-3 alkyleneOC1-3 fluroroalkyl, NH2, NH(C1-3 alkyl), C1-3 alkylene-NH2, C1-3 alkyleneNH(C1-3 alkyl), N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, C1-3 alkyleneN(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, C(O)OH, C(O)OC1-5 alkyl, C1-3 alkyleneC(O)OH, C1-3 alkyleneC(O)OC1-5 alkyl, OC(O)H, OC(O)C1-5 alkyl, C1-3 alkyleneOC(O)H, C1-3 alkyleneOC(O)C1-5 alkyl, NHC(O)H, NHC(O)C1-5 alkyl, N(C1-3 alkyl)C(O)H, N(C1-3 alkyl)C(O)C1-5 alkyl, C1-3 alkyleneNHC(O)H, C1-3 alkyleneNHC(O)C1-5 alkyl, C1-3 alkyleneN(C1-3 alkyl)C(O)H, C1-3 alkyleneN(C1-3 alkyl)C(O)C1-5 alkyl, C(O)NH2, C(O)NH(C1-3 alkyl), C1-3 alkyleneC(O)NH2, C1-3 alkyleneC(O)NH(C1-3 alkyl), C(O)N(C1-5 alkyl)2, in which the C1-5 alkyl are the same or different, C1-3 alkyleneC(O)N(C1-5 alkyl)2, in which the C1-5 alkyl are the same or different, nitro, C(O)H, C(O)C1-C5 alkyl, NHSO2C1-C3 alkyl, N(C1-C3 alkyl)SO2C1-C3 alkyl, NHSO2C1-C3 fluoroalkyl, N(C1-C3 alkyl)SO2C1-C3 fluoroalkyl, OC2-C3alkyleneNH2, OC2-C3alkyleneNH(C1-C3 alkyl), OC2-C3alkyleneN(C1-C3 alkyl)2 in which the C1-3 alkyl are the same or different, and
• wherein
• D is selected from the group consisting of a bond, C1-3 alkylene, O—C1-3 alkylene, C1-3 alkylene-O—C1-3 alkylene, OC(O)C1-3 alkylene, C1-3 alkylene-OC(O)-C1-3 alkylene, C(O)OC1-3 alkylene, C1-3 alkylene-C(O)O—C1-3 alkylene, C(O)N(H)(C1-3 alkylene), C(O)N(C1-3 alkyl)(C1-3 alkylene), C1-3 alkylene-C(O)N(H)(C1-3 alkylene), C1-3 alkylene-C(O)N(C1-3 alkyl)(C1-3 alkylene), N(H)C(O)C1-3 alkylene, N(C1-3 alkyl)C(O)C1-3 alkylene, C1-3 alkylene-N(H)C(O)C1-3 alkylene, C1-3 alkylene-N(C1-3 alkyl)C(O)C1-3 alkylene, —NHSO2-, —SO2NH—, SO2, SO, C(O), C1-3 alkylene-C(O), C(O)C1-3 alkylene, C1-3 alkylene C(O)C1-3 alkylene, NH, N(C1-3 alkyl), NH-C1-3 alkylene, N(C1-3 alkyl)-C1-3 alkylene, C1-3 alkylene-NH, C1-3 alkylene-N(C1-3 alkyl), C1-3 alkylene-NH-C1-3 alkylene, C1-3 alkylene-N(C1-3 alkyl)-C1-3 alkylene, and S;
• Cy2 is a phenyl, or a C3-8 non-aromatic carbocycle;
• m is an integer selected from the group consisting of 0, 1, 2, 3, 4, and 5;
• R6 is independently selected from oxo, C1-5 alkyl, C1-5 fluoroalkyl, halo, cyano, —CH2-cyano, —OH, OC1-5 alkyl, C1-5 alkylene-OH, C1-5 alkyleneOC1-5 alkyl, —SH, SC1-5 alkyl, SO2H, SO2C1-5 alkyl, C1-3 alkyleneSO2H, C1-3 alkyleneSO2C1-5 alkyl, OC1-3 fluoroalkyl, C1-3 alkyleneOC1-3 fluoroalkyl, NH2, NH(C1-3 alkyl), C1-3 alkylene-NH2, C1-3 alkylene-NH(C1-3 alkyl), N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, C1-3 alkyleneN(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, C(O)OH, C(O)OC1-5 alkyl, C1-3 alkylene-C(O)OH, C1-3 alkylene-C(O)OC1-5 alkyl, OC(O)H, OC(O)C1-5 alkyl, C1-3 alkylene-OC(O)H, C1-3 alkylene-OC(O)C1-5 alkyl, NHC(O)H, NHC(O)C1-3 alkyl, N(C1-3 alkyl)C(O)H, N(C1-3 alkyl)C(O)C1-3 alkyl, C1-3 alkylene-NHC(O)H, C1-3 alkylene-NHC(O)C1-3 alkyl, C1-3 alkylene-N(C1-3 alkyl)C(O)H, C1-3 alkylene-N(C1-3 alkyl)C(O)C1-3 alkyl, C(O)NH2, C(O)NH(C1-3 alkyl), C1-3 alkylene-C(O)NH2, C1-3 alkylene-C(O)NH(C1-3 alkyl), C(O)N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, C1-3 alkyleneC(O)N(C1-5 alkyl)2 in which the C1-5 alkyl are the same or different, C(O)N(C4-5 alkylene), C1-3 alkyleneC(O)N(C4-5 alkylene), nitro, C(O)H, C(O)C1-C5 alkyl, C(O)C1-C3 fluoroalkyl, NHSO2C1-C3 alkyl, N(C1-C3 alkyl)SO2C1-C3 alkyl, NHSO2C1-C3 fluoroalkyl, N(C1-C3 alkyl)SO2C1-C3 fluoroalkyl, OC2-C3alkyleneNH2, OC2-C3alkyleneNH(C1-C3 alkyl), and OC2-C3alkyleneN(C1-C3 alkyl)2 in which the C1-3 alkyl are the same or different;
• or
• when two R6 are present, each R6 is combined to form a fused ring or spiro ring with Cy2;
• n is an integer selected from the group consisting of 0, 1, and 2;
• as a free base, an acid in its non-charged protonated form, a pharmaceutically acceptable addition salt, a pure diastereomer, a pure enantiomer, a diastereomeric mixture, a racemic mixture, a scalemic mixture, a corresponding tautomeric form resulting from a hydrogen shift between two hetero-atoms and/or the corresponding tautomeric form resulting from a keto-enol tautomerization.