Dengue vaccines
AssigneeOxford University Innovation Limited
InventorsArturo Reyes-Sandoval, Cesar Lopez-Camacho, Joshua Blight
Life of this patent
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Abstract
The invention relates to a protein comprising a plurality of conserved peptide sequences, or variants thereof, wherein at least one of the conserved sequences is conserved across all four dengue virus serotypes DENV-1, DENV-2, DENV-3 and DENV-4, and wherein the conserved sequences comprise at least part of a sequence of one or more non-structural proteins of the dengue virus serotypes. The invention further relates to associated peptides, compositions, nucleic acids, viral vectors, virus-like particles, use, prime boost vaccination kits, agents and methods.
Claims7
A nucleic acid comprising a sequence encoding a fusion protein, wherein the fusion protein comprises the peptide sequences of SEQ ID NO:
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- wherein the variants of the peptide sequences comprise sequences having at least 80% identity with the peptide sequences.
Dependencies are inferred from the claim text.