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AssigneeSusavion Biosciences, Inc.
InventorsLaura L. Eggink, J. Kenneth Hoober
Estimating the term…
The methods and compounds disclosed herein are useful in treating a subject having cancer or a viral infection by modulating the innate and adaptive immune systems typically by both inhibiting the function of inhibitory receptors and enhancing activity of activating receptors. Preferred therapeutic compositions comprise a carrier; at least one agent selected from the group consisting of: an anti-inflammatory agent, a cytotoxic T cell proliferation agent, or a NK cell proliferation agent; and a therapeutic peptide of the invention. In certain embodiments the compositions further include a second therapeutic peptide and/or an immunoglobulin admixed therewith in an amount sufficient to enhance passive immunoprotection in the subject.
A method of treating a subject having cancer, a viral infection, or both, comprising administering to the subject a first therapeutic peptide or a first multivalent structured polypeptide comprising multiple copies of the first therapeutic peptide, wherein the first therapeutic peptide consists of 6 to 8 amino acids comprising NQHTPR (SEQ ID NO:5), and the first therapeutic peptide or first multivalent structured polypeptide is in an amount sufficient to treat the cancer, the viral infection, or both in the subject.
A therapeutic composition, comprising:
Dependencies are inferred from the claim text.