Pharmaceutical glass packaging assuring pharmaceutical sterility

A sterile packaged pharmaceutical composition comprising:

• a sterile pharmaceutical container comprising a delamination resistant glass and a sterile pharmaceutical composition contained in the sterile pharmaceutical container comprising:
• an active pharmaceutical ingredient;
• and
• wherein the sterile pharmaceutical container comprises:
• a first surface and a second surface separated by glass having a thickness;
• a first region under a compressive stress, the first region extending from at least one of the first surface and the second surface to a depth of layer in the glass of at least about 10 μm;
• and
• a second region under a central tension of at least about 15 MPa, the second region extending from the depth of layer, wherein the central tension is greater than a central tension that is sufficient to allow self-propagation of a crack front through the thickness from the first surface to the second surface which renders the pharmaceutical container unsuitable for its intended use such that the active pharmaceutical ingredient remains sterile so long as the crack front does not extend into the second region;
• and
• wherein the glass comprises a laminate, the laminate comprising a first glass disposed on the first surface and a second glass disposed between the first glass and the second surface.