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US 10,344,263 B2Granted
Synthetic membrane-receiver complexes
AssigneeRubius Therapeutics, Inc.
InventorsAvak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
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Abstract
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
Claims25
A method of making an erythroid cell comprising at least 1,000 copies of an exogenous polypeptide comprising phenylalanine ammonia lyase (PAL), comprising:
- i) introducing an exogenous nucleic acid encoding the exogenous polypeptide into an erythroid cell precursor;
- and
- ii) culturing the erythroid cell precursor to provide the erythroid cell comprising the exogenous polypeptide,
- wherein the erythroid cell comprising said exogenous polypeptide is not a hypotonically loaded cell.
1 more element
Dependencies are inferred from the claim text.