Anti-parasitic complexes

A complex comprising at least one component A and at least one component B, characterized in that component A is an antibody or antibody fragment that has a binding activity for cellular surface structures presented on the surface of a parasite of the genus Plasmodium and component B is a variant of human granzyme B having direct anti-parasitic activity, wherein the cellular surface structure is selected from the group consisting of cell traversal protein for ookinetes and sporozoites (CelTos), circumsporozoite protein (CSP), Exported Protein 1 (EXPO, Merozoite surface protein 1 (MSP1), Merozoite surface protein 2 (MSP2), Merozoite surface protein 3 (MSP3), Merozoite surface protein 4 (MSP4), Merozoite surface protein 5 (MSPS), Merozoite surface protein 7 (MSP7), Merozoite surface protein 8 (MSPS), Merozoite surface protein 9 (MSPS), Merozoite surface protein 10 (MSP10), Merozoite-specific thrombospondin-related anonymous protein (mTRAP), Plasmodium falciparum 6-cys protein (Pf38), Reticulocyte binding protein homologue 1 (Rh1), Reticulocyte binding protein 2 homolog a (Rh2a), Reticulocyte binding protein 2 homologue b (Rh2b), Reticulocyte binding protein homologue 4 (Rh4), Reticulocyte binding protein homologue 5 (Rh5), Rh5 interacting protein (Ripr), rhoptry neck protein 2 (RON2), rhoptry neck protein 4 (RON4), rhoptry neck protein 5 (RON5), Plasmodium falciparum rhoptry neck protein 6 (PfRON6), Thrombospondin-related apical membrane protein (TRAMP), Apical membrane antigen 1 (AMA1), Glutamine rich protein (GLURP), High Molecular Weight Rhoptry Protein-2 (RhopH2) and High Molecular Weight Rhoptry Protein-3 (RhopH3), and wherein the variant of human granzyme B comprises an amino acid sequence selected from the group consisting of SEQ ID NO:

• 7, SEQ ID NO:
• 8, SEQ ID NO:9, and SEQ ID NO:
• 10.