Process for the preparation of the compound N-(3,5-dimethylphenyl)-N′-(2-trifluoromethylphenyl) guanidine
AssigneeChemo Research, S.L.
InventorJosé Amato
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N′-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins.
Claims13
A process for the preparation of a crystalline solid form A of the compound N-(3,5-dimethylphenyI)-N′-(2-trifluoromethylphenyl) guanidine of formula (I),
- showing a DSC of 132.4° C.,
- which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II)
- with a cyanamide compound of formula (III),
- in the presence of a polar organic solvent.
A crystalline solid form A of the compound N-(3,5-dimethylphenyl)-N′-(2-trifluoromethylphenyl) guanidine of formula (I) showing a melting point of 131.5° C.
Dependencies are inferred from the claim text.