TCO conjugates and methods for delivery of therapeutic agents
AssigneesThe Regents of the University of California, The Research Foundation for The State University of New York
InventorsJose Manuel Mejia Oneto, Maksim Royzen
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Abstract
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
Claims19
A bioactive composition comprising:
- a therapeutic agent other than doxorubicin, vancomycin, and paclitaxel;
- a binding agent comprising a trans-cyclooctene;
- and
- a linker comprising from about 1 to about 10 linking atoms, covalently linking the binding agent to the therapeutic agent.
A bioactive composition comprising a therapeutic agent other than doxorubicin, wherein the therapeutic agent is linked by a covalent bond to a structure
A bioactive composition comprising:
- a diagnostic agent;
- a binding agent comprising a trans-cyclooctene;
- and
- a linker comprising from about 1 to about 10 linking atoms, covalently linking the binding agent to the diagnostic agent.
Dependencies are inferred from the claim text.