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US 10,337,007 B2Granted
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
AssigneeIonis Pharmaceuticals, Inc.
InventorsSusan M. Freier, Eric E. Swayze
Life of this patent
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Abstract
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
Claims9
A compound comprising:
- a modified oligonucleotide consisting of 16 to 20 linked nucleosides, wherein the modified oligonucleotide comprises a sugar motif of e-k-k-(D)9-k-e-k-e, wherein each “k” comprises a bicyclic nucleoside, each “e” comprises a 2′-substituted nucleoside, and each “D” comprises a 2′-deoxynucleoside;
- and wherein each 2′-substituent is selected from among:
- 2′-OMe, 2′-O-methoxyethyl, and 2′-F;
- and wherein the nucleobase sequence of the modified oligonucleotide is complementary to the nucleobase sequence of a target nucleic acid.
1 more element
Dependencies are inferred from the claim text.