Method for industrial production of optically active fluoroalkyl ethylene oxide
AssigneeCentral Glass Company, Limited
InventorsTetsuro Nishii, Ayumi Yamaguchi, Takashi Ootsuka, Naoki Sawai
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Abstract
It is possible to produce an optically active fluoroalkyl chloromethyl alcohol with a high optical purity and a good yield by treating a fluoroalkyl chloromethyl ketone with a microorganism having an activity for asymmetrically reducing the ketone or an enzyme having the activity. Then, it is possible to obtain a fluoroalkyl ethylene oxide by treating the alcohol with a base. Industrial implementation of the production method of the present invention is easy.
Claims16
A method for producing an optically active fluoroalkyl chloromethyl alcohol represented by formula [2]:
- wherein, * represents an asymmetric atom, and Rf is defined as in formula [1],
- the method comprising the step of treating a fluoroalkyl chloromethyl ketone represented by formula [1]:
- wherein, Rf represents a C1-6 straight-chain or branched-chain fluoroalkyl group having at least one fluorine atom,
- with a microorganism having an activity for asymmetrically reducing the ketone or an enzyme having the activity.
An optically active 1-chloro-3,3-difluoroisopropyl alcohol represented by formula:
- wherein, * represents an asymmetric atom.
Dependencies are inferred from the claim text.