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US 10,336,675 B2Granted
Biaromatic vitamin D analogs
AssigneeDsm IP Assets B.V.
InventorsIgor Bendik, Piero Geotti-Bianchini, Marc Heidl, Eileen Jackson, Alexander Schlifke-Poschalko
Life of this patent
Estimating the term…
Abstract
Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.
Claims16
A compound according to formula (I):
- wherein
- X and Y, are either both —CH2—, or one of X and Y is —CH2— and the other is —O—;
- R1 is a methyl group or an ethyl group;
- A is either a carbon atom, CH group, CH2 group or an oxygen atom;
- one of Z1 and Z2 represents a hydroxyl group and the other one is a hydrogen atom;
- R2 and R3, independently of each other, represent a hydrogen atom, a methyl group, an ethyl group, or a CF3 group or R2 and R3, together with the carbon they are bound to, form a cyclopropyl group;
- the dotted/solid lines () represent either a single carbon-carbon bond or a double carbon-carbon bond, with the proviso that, if two of said bonds are double bonds, the double bonds are conjugated;
- one of R6 and R7 represents a hydrogen atom and the other one represents a radical R8, wherein
- wherein R4 represents a hydrogen atom, a methyl group, an ethyl group, a propyl group, a (CH2)nOR9 group where n is 1, 2, 3 or 4;
- and R5 represents a hydrogen atom, a methyl group, an ethyl group, a propyl group, or a (CH2)nOR10 group where n is 1, 2 or 3, and wherein
- R9 and R10, independently of each other, represent a hydrogen atom, a methyl group, or an ethyl group.
8 more elements
A compound according to formula (I-a):
A compound according to formula (I-b):
A compound according to formula (I-c):
A compound according to formula (I-d):
A compound according to formula (I-e):
A compound according to formula (I-f):
Dependencies are inferred from the claim text.