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US 10,333,018 B2Granted
Cytometer sperm sex sensing apparatus with an avalanche photodiode
AssigneePremium Genetics (UK) Ltd.
InventorsFrederick Hershel Savage, Glenn J. Szejna, Zheng Xia
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Abstract
A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.
Claims15
A flow cytometry apparatus comprising:
- a flow chamber configured to direct a fluid stream including cells through an interrogation location;
- a laser configured to emit electromagnetic radiation along a beam path to the interrogation location to illuminate a given cell;
- an avalanche photodiode configured to:
- receive electromagnetic radiation from the interrogation location emitted by the given cell;
- and
- generate a signal indicative of an intensity of the received electromagnetic radiation;
- at least one processor configured to analyze the signal indicative of the intensity of the received electromagnetic radiation to determine a characteristic of the given cell;
- a switching power supply including a feedback loop;
- a temperature sensor configured to sense a temperature and generate a corresponding temperature signal encoding temperature data;
- and
- voltage adjustment circuitry configured to adjust a voltage on the feedback loop based at least in part on the temperature data.
8 more elements
A flow cytometry apparatus comprising:
- a flow chamber configured to direct a fluid stream including cells through an interrogation location;
- a laser configured to emit electromagnetic radiation along a beam path to the interrogation location to illuminate a given cell;
- an avalanche photodiode configured to:
- receive electromagnetic radiation from the interrogation location emitted by the given cell;
- and
- generate a signal indicative of an intensity of the received electromagnetic radiation;
- at least one processor configured to analyze the signal indicative of the intensity of the received electromagnetic radiation to determine a characteristic of the given cell;
- and
- circuitry configured to deliver a signal indicative of the intensity of the received electromagnetic radiation in a digital form to the at least one processor, wherein the circuitry is interposed between the avalanche photodiode and the at least one processor and further wherein the circuitry comprises:
- a first amplifier configured to receive in an analog form, amplify, and output the signal indicative of the intensity of the received electromagnetic radiation from the avalanche photodiode;
- a second amplifier configured to receive in the analog form, amplify, and invert the output of the first amplifier;
- and
- at least one analog-to-digital converter configured to convert the signal indicative of the intensity of the received electromagnetic radiation into the digital form.
10 more elements
Dependencies are inferred from the claim text.