Methods of detecting bladder cancer
AssigneeCepheid
InventorsLeena McCann, Stacey Ellen Wallace, Edwin Wei-Lung Lai, Russell Higuchi
Life of this patent
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Abstract
Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of detecting low grade bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting androgen receptor (AR) and/or uroplakin 1B (UPK1B).
Claims29
A method for detecting the presence of uroplakin 1B (UPK1B) and at least one marker selected from androgen receptor (AR), corticotrophin releasing hormone (CRH), insulin-like growth factor 2 (IGF2), keratin 20 (KRT20) and annexin 10 (ANXA10) in a urine sample from a human subject comprising (a) obtaining the urine sample from the human subject;
- (b) isolating nucleic acid from the sample;
- and (c) detecting UPK1B and at least one additional marker selected from AR, CRH, IGF2, KRT20, and ANXA10 by performing a polymerase chain reaction (PCR) comprising contacting the nucleic acid from the sample with a set of two to six bladder cancer marker primer pairs.
Dependencies are inferred from the claim text.