Compositions and methods for modulating an immune response
AssigneeThe Johns Hopkins University
InventorsCharles G. Drake, Drew M. Pardoll, Jonathan D. Powell, Derese Getnet, Edward L. Hipkiss, Joseph F. Grosso
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Abstract
The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.
Claims18
A method for increasing an effector T cell-mediated immune response, the method comprising contacting one or more cells with an inhibitory nucleic acid molecule that reduces Helios expression or biological activity, and reduces Treg CD4+CD25+T lymphocyte suppression of an effector T cell mediated immune response.
A method for increasing an effector T cell-mediated immune response in a subject in need thereof, the method comprising administering to the subject an effective amount of an inhibitory nucleic acid molecule that reduces Helios expression or biological activity, and reduces Treg CD4+CD25+T lymphocyte suppression of an effector T cell mediated immune response in the subject.
A method for increasing the efficacy of an anti-neoplasia vaccine in a subject, the method comprising administering to the subject a vaccine comprising a tumor antigen and an inhibitory nucleic acid molecule that reduces the level or activity of a Helios polypeptide, and reduces Treg CD4+CD25+T lymphocyte suppression of an effector T cell mediated immune response in a cell of the subject.
Dependencies are inferred from the claim text.