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US 10,329,612 B2Granted
Compositions and processes for improved mass spectrometry analysis
AssigneeAgena Bioscience, Inc.
InventorThomas Becker
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Abstract
The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present in mass spectra. The improved processes and compositions of the invention allow for increased accuracy, sensitivity and throughput for samples analyzed by mass spectrometry.
Claims17
A method of preparing a substrate suitable for use in Matrix-Assisted Laser Desorption/Ionization mass spectrometry, comprising depositing a matrix material comprising an adduct-reducing additive, on the substrate, wherein:
- the matrix material is deposited on the substrate in an array of spots;
- and
- the adduct-reducing additive comprises ascorbic acid, or a salt, tautomer or analog thereof, in an amount that reduces the amount of an adduct formed under mass spectrometry conditions.
Dependencies are inferred from the claim text.