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AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsAndreas Gallei, Ramesh Koukuntla, Robert Barry Mandell, Alice Mundt, Kristina Rehmet, Eric Martin Vaughn
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The present invention relates to the field of CAdV vector vaccines, and especially to promoters suitable to express target antigens from such vector vaccines. Disclosed and claimed are recombinant canine adenoviruses, methods of making them, uses for them (including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning, replicating or expressing DNA and methods of using the compositions and vector), expression products from them, and uses for the expression products. Additionally, disclosed and claimed are truncated EHV4 promoters, expression cassettes containing the promoters, and recombinant viruses and plasmids containing the promoters or expression cassettes.
A recombinant canine adenovirus (rCAdV) vector comprising an expression cassette encoding a heterologous DNA operably linked to an equine herpesvirus-4 (EHV4) promoter sequence, wherein the EHV4 promoter sequence is either (i) an EHV4 ORF 42 promoter sequence comprising a polynucleotide having at least 95% sequence identity to SEQ ID NO:
Dependencies are inferred from the claim text.