Modified Sendai virus vaccine and imaging vector
AssigneeSt. Jude Children's Research Hospital
InventorsJulia Lea Hurwitz, Toru Takimoto, Charles John Russell, Allen Portner, Karen Slobod
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Abstract
The present invention relates to a Sendai virus or recombinant Sendai virus vector. In particular the present invention provides methods, vectors, formulations, compositions, and kits for a modified Enders strain Sendai viral vector. An immunogenic vector can be used in any in vitro or in vivo system. Moreover, some embodiments include vectors for imaging virus growth, location and transmission.
Claims11
A composition comprising a recombinant Enders/Z chimera Sendai viral vector comprising a modified Enders strain Sendai virus L gene, wherein said modified Enders strain Sendai virus L gene comprises wild type Enders strain Sendai virus L gene that contains nucleic acid sequence encoding at least one amino acid substitution with a corresponding different amino acid from wild type Z strain Sendai virus L gene, said at least one amino acid substitution is selected from the group consisting of S to G at position 155, R to K at position 258, G to E at position 466, G to E at position 482, S to Rat position 581, Q to Rat position 71 7, T to I at position 800, R to K at position 852, and combinations thereof.
Dependencies are inferred from the claim text.