Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses
AssigneeOlogy Bioservices, Inc.
InventorsFalko-Günter Falkner, Birgit Schafer, P Noel Barrett, Thomas R. Kreil, Hartmut Ehrlich, Annett Hessel
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Abstract
The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A viruses. The invention provides recombinant viral vectors based, for example, on the non-replicating modified vaccinia virus Ankara. When administered according to methods of the invention, the recombinant viral vectors are designed to be cross-protective and induce heterosubtypic immunity to influenza A viruses.
Claims17
A recombinant modified vaccinia virus Ankara (rMVA) comprising a gene cassette encoding a fusion protein comprising at least one influenza A M2 extracellular domain (M2e) polypeptide inserted in an influenza A headless hemagglutinin (h1HA) polypeptide set out in SEQ ID NO:
- 15.
A recombinant vaccinia virus comprising the gene cassette set out in SEQ ID NO:
- 1.
A recombinant modified vaccinia virus Ankara (rMVA) comprising a first gene cassette encoding a fusion protein comprising at least one influenza A M2 extracellular domain (M2e) polypeptide inserted in an influenza A headless hemagglutinin (h1HA) polypeptide and a second gene cassette encoding influenza A nucleoprotein (NP) set out in SEQ ID NO:
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Dependencies are inferred from the claim text.