Back to results
US 10,329,563 B2Granted
Organic compositions to treat HSF1-related diseases
AssigneeArrowhead Pharmaceuticals, Inc.
InventorsJinyun Chen, Kalyani Gampa, Dieter Huesken, Frank Stegmeier, Mark Stump, Chandra Vargeese, Jan Weiler, Wenlai Zhou
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to methods of treating heat stock factor 1 (HSF1)-related diseases such as cancer, autoimmune and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
Claims13
A composition comprising a RNAi agent for inhibiting the expression of HSF1, the RNAi agent comprising a sense strand and an antisense strand, wherein the antisense strand comprises at least 19 contiguous nucleotides differing by 0 or 1 nucleotides from:
- (i) the antisense strand sequence UUAGCAUAGAGCCUGUCUG (SEQ ID NO:
- 178);
- or
- (ii) the antisense strand sequence UUUAGCAUAGAGCCUGUCU (SEQ ID NO:
- 179);
- wherein the antisense strand comprises at least one modified backbone and/or at least one 2′-modified nucleotide, and wherein the sense strand is at least substantially complementary to the antisense strand.
3 more elements
Dependencies are inferred from the claim text.