HBV RNAse H purification and enzyme inhibitors

A method of inhibiting a hepatitis B virus (HBV) RNAseH comprising contacting said enzyme with a compound having the formula:

• wherein:
• R11 is hydrogen, —OR17, hydroxy, or halo, wherein R17 is C1-C8 acyl, C1-C8 alkyl, or a substituted version of either of these groups;
• R12 is hydrogen, hydroxy or halo;
• R13 and R14 are each independently hydrogen, hydroxy, nitroso, C1-C12 alkyl, C1-C12 alkenyl, C1-C12 alkynyl, C1-C12 aryl, C1-C12 aralkyl, C1-C12 amido, a substituted version of any of these groups, or R13 is taken together with R14 as provided below;
• R15 is hydrogen, C1-C12 alkyl, C1-C12 alkenyl, C1-C12 alkynyl, C1-C12 aryl, C1-C12 aralkyl,
• or a substituted version of any of these groups;
• and
• R16 is hydrogen, unsubstituted C1-C6 alkyl, substituted C1-C6 alkyl, or hydroxyl;
• provided that when R13 and R14 are taken together as further defined by FORMULA IV:
• R18 and R19 are each independently hydrogen, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl.