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US 10,329,539 B1Granted
Recombinant B11 bacteriophages and uses thereof
AssigneeThe Charles Stark Draper Laboratory, Inc.
InventorsConnor McBrine, Georgiana Kourepenos, Parker Dow, Jason Holder
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Abstract
The present disclosure provides compositions including recombinant B11 bacteriophages, methods for making the same, and uses thereof. The recombinant B11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
Claims21
A recombinant B11 bacteriophage nucleic acid sequence, wherein the nucleic acid sequence between position 65,939 and position 65,940 of SEQ ID NO:
- 1 is replaced with a heterologous nucleic acid sequence comprising an open reading frame that encodes a reporter protein, wherein the reporter protein is a bioluminescent protein, a fluorescent protein, or a chemiluminescent protein.
Dependencies are inferred from the claim text.