Enhanced placental stem cells and uses thereof
AssigneeCelularity Inc.
InventorsStewart Abbot, Kathy Karasiewicz-Mendez, Xiaokui Zhang
Life of this patent
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Abstract
Provided herein are placental stem cells that exhibit increased survival (“enhanced placental stem cells”), compositions comprising such placental stem cells, and methods of using such placental stem cells and compositions.
Claims17
An isolated placental stem cell, wherein said placental stem cell has been modified to comprise or express miR-16 or miR-424, and wherein said placental stem cell demonstrates increased survival relative to corresponding unmodified placental stem cells when cultured under one or more conditions that cause cell death.
A method of producing placental stem cells that comprise or express miR-16 or miR-424, wherein said placental stem cells demonstrate increased survival relative to corresponding unmodified placental stem cells when cultured under one or more conditions that cause cell death, said method comprising contacting a population of placental stem cells with an effective amount of miR-16 or miR-424, such that said placental stem cells, after having been contacted with said miR-16 or miR-424 express Cyclin D3 or Cyclin E at a decreased level as compared to the expression of Cyclin D3 or Cyclin E in an equivalent amount of placental stem cells not contacted with said miR-16 or miR-424.
Dependencies are inferred from the claim text.