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US 10,329,358 B2Granted
Anti-human membrane-type ADAM28 antibody
AssigneesGeneFrontier Corporation, Keio University
InventorsAkira Miyakoshi, Kanehisa Kojoh, Satsuki Mochizuki, Masayuki Shimoda, Yasunori Okada
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Abstract
The present invention provides an antibody having an activity to specifically bind to human membrane-anchored form ADAM28 at an epitope in a region of the 524th-659th amino acids in the amino acid sequence shown in SEQ ID NO: 2. In addition, the present invention provides a drug delivery vehicle for delivering a drug to a cell or tissue that expresses human membrane-anchored form ADAM28, which contains the antibody.
Claims14
An antibody comprising a light chain variable region and a heavy chain variable region,
- wherein the antibody has an activity to specifically bind to human membrane-anchored form ADAM28,
- wherein the antibody binding site on human membrane-anchored form ADAM28 is located in a region consisting of the 524th-659th amino acids in the amino acid sequence shown in SEQ ID NO:
- 2,
- wherein the light chain variable region comprises CDR1 comprising the amino acid sequence shown in SEQ ID NO:
- 5, CDR2 comprising the amino acid sequence shown in SEQ ID NO:
- 6, and CDR3 comprising the amino acid sequence shown in SEQ ID NO:
- 7, and
- wherein the heavy chain variable region comprises CDR1 comprising the amino acid sequence shown in SEQ ID NO:
- 8, CDR2 comprising the amino acid sequence shown in SEQ ID NO:
- 9, and CDR3 comprising the amino acid sequence shown in SEQ ID NO:
- 10.
8 more elements
Dependencies are inferred from the claim text.