Compositions and methods for targeting stromal cells for the treatment of cancer
AssigneesThe Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology
InventorsCarl H. June, Ellen Pure, Liang-Chuan Wang, Steven Albelda, John Scholler
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Abstract
The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.
Claims9
An isolated chimeric antigen receptor (CAR) comprising an antigen binding domain encoded by a nucleic acid sequence comprising SEQ ID NO:
- 3, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the antigen binding domain binds to a stromal cell antigen.
Dependencies are inferred from the claim text.