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US 10,329,347 B2Granted
Compositions comprising soluble CD84 or anti-CD84 antibodies and methods for diagnosing and treating B-CLL
AssigneeYeda Research and Development Co. Ltd.
InventorsIdit Shachar, Inbal Binsky, Mirko Sobotta
Life of this patent
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Abstract
A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL.
Claims8
A method of diagnosing and treating B-CLL in a subject in need thereof, the method comprising:
- (a) detecting expression of CD84 isoform C (SEQ ID NO:
- 30) in a biological sample from the subject;
- (b) diagnosing the subject with B-CLL when an increase in a level of said CD84 isoform C (SEQ ID NO:
- 30) is detected beyond a predetermined threshold with respect to said level of said CD84 isoform C in a biological sample from a healthy individual;
- and (c) administering to the diagnosed subject a therapeutic agent which decreases an activity or expression of CD84, wherein said agent is selected from the group consisting of a soluble CD84 and a nucleic acid agent for silencing CD84 expression, thereby diagnosing and treating B-CLL in the subject.
2 more elements
A method of diagnosing B-CLL in a subject in need thereof, the method comprising:
- (a) detecting whether CD84 isoform C (SEQ ID NO:
- 30) is present in a biological sample from the subject by contacting the biological sample with the anti-CD84 antibody produced by the hybridoma which has been deposited at the CNCM Pasteur Institute under the deposit number CNCM I-4228 (F8), and detecting binding between CD84 isoform C and said anti-CD84 antibody;
- and (b) diagnosing the subject with B-CLL when an increase in a level of said CD84 isoform C beyond a predetermined threshold with respect to a level of said CD84 in a biological sample from a healthy individual is detected.
Dependencies are inferred from the claim text.