Back to results
US 10,329,343 B2Granted
Methods for treating headache using antagonist antibodies directed against calcitonin gene-related peptide
AssigneeTeva Pharmaceuticals International GmbH
InventorsJoerg Zeller, Kristian Todd Poulsen, Yasmina Noubia Abdiche, Jaume Pons, Sierra Jones Collier, Arnon Rosenthal
Life of this patent
Estimating the term…
Abstract
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.
Claims24
A method for treating headache in an individual, comprising:
- administering to the individual an effective amount of a humanized monoclonal anti-Calcitonin Gene-Related Peptide (CGRP) antagonist antibody and at least one additional agent,
- wherein the antagonist antibody comprises:
- two IgG heavy chains, each heavy chain comprising a VH domain comprising the amino acid sequence of SEQ ID NO:1;
- and
- two light chains, each light chain comprising a VL domain comprising the amino acid sequence of SEQ ID NO:2.
2 more elements
Dependencies are inferred from the claim text.