Collagen mimics
AssigneeWisconsin Alumni Research Foundation
InventorsRonald T. Raines, Matthew D. Shoulders, Jonathan A. Hodges
Life of this patent
Estimating the term…
Abstract
Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly)n,where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.
Claims12
A composition of matter comprising a triple helix of collagen mimic molecules in which each of the molecules in the helix comprises tripeptides of the formula:
- (flp-Yaa-Gly)n,
- where Yaa is a (2S,4S)-4-alkylproline or a (2S,4S)-4-thioproline,
- where flp is (2S,4S)-4-fluoroproline, and
- n is a positive integer.
A composition of matter comprising a triple helix of collagen mimic molecules in which each of the molecules in the helix comprises tripeptides of the formula:
- (Xaa-Flp-Gly)n,
- where Xaa is selected from the group consisting of (2S,4R)-4-alkylproline or a (2S,4R)-4-thioproline,
- where Flp is (2S,4R)-4-fluoroproline, and
- n is a positive integer.
Dependencies are inferred from the claim text.