Anti-human papillomavirus 16 E6 T cell receptors
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsChristian S. Hinrichs, Steven A. Rosenberg
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Abstract
Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
Claims20
An isolated or purified nucleic acid comprising a nucleotide sequence encoding a polypeptide comprising the alpha chain CDR1 amino acid sequence of SEQ ID NO:
- 3, the alpha chain CDR2 amino acid sequence of SEQ ID NO:
- 4, the alpha chain CDR3 amino acid sequence of SEQ ID NO:
- 5, the beta chain CDR1 amino acid sequence of SEQ ID NO:
- 6, the beta chain CDR2 amino acid sequence of SEQ ID NO:
- 7, and the beta chain CDR3 amino acid sequence of SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.