Antimicrobial kinocidin compositions and methods of use
AssigneeLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
InventorsNannette Y. Yount, Michael R. Yeaman
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Abstract
The present invention provides novel kinocidin peptides comprising a C-terminal portion of a kinocidin, wherein the C-terminal portion encompasses an α-helical secondary structure and further displays antimicrobial activity. The kinocidin peptides of the invention are derived from and correspond to a C-terminal portion of a kinocidin that includes a γKO core and that can be a CXC, CC, or C class chemokine. Structural, physicochemical and functional properties of this novel class of antimicrobial peptides and amino acid sequences of particular kinocidin peptides are also disclosed. The invention also provides related antimicrobial methods.
Claims17
A method for treating an infectious disease or condition in a subject in need of such treatment, comprising administering to the subject an effective amount of a peptide which (a) is 15 to 50 amino acid residues in length, (b) comprises a fragment of a C-terminal alpha-helical motif of a kinocidin protein selected from the group consisting of human CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28 and CL1, and (c) has microbicidal activity.
Dependencies are inferred from the claim text.