Controlled gene expression methods

A method of inhibiting a disease or disorder in a subject comprising administering to said subject a composition comprising i) a nucleic acid molecule encoding a polypeptide comprising a DNA binding domain and a looping factor, wherein said looping factor is a fragment of LIM domain binding 1 (Ldb1), and ii) at least one pharmaceutically acceptable carrier,

• wherein said fragment of Ldb1 comprises an amino acid sequence having at least 90% identity with amino acids 1 to 200 of SEQ ID NO:
• 1.