HPV-related fusion protein and applications thereof
AssigneeAttogen Biomedical (Suzhou) Inc. Ltd.
InventorsXiaojia Chang, Chenglong Shi, Lijun Shi, Jiecheng Zhang
Life of this patent
Estimating the term…
Abstract
A fusion protein has a first antigen element, a second antigen element, and optionally a tag sequence and/or a signal peptide sequence. The first antigen element includes a polypeptide derived from the Mycobacterium tuberculosis Psts-1 protein. The second antigen element includes a polypeptide derived from a protein encoded by a HPV gene. The fusion protein can induce humoral immunity and cellular immunity to a high-risk HPV cancer protein and has anti-cancer activity in vivo.
Claims16
A fusion protein, wherein the fusion protein comprises a first antigen element, a second antigen element, and optionally a tag sequence and/or a signal peptide sequence,
- wherein the first antigen element comprises a polypeptide derived from the Mycobacterium tuberculosis Psts-1 protein;
- the second antigen element comprises a polypeptide derived from a protein encoded by a HPV gene;
- and
- the second antigen element is one or more selected from the group consisting of an antigen element A, an antigen element B, an antigen element C, and an antigen element D,
- wherein the antigen element A is a polypeptide derived from HPV16 L2 protein, the antigen element B is a polypeptide derived from HPV16 E6 protein, the antigen element C is a polypeptide derived from HPV16 E7 protein, and the antigen element D is a polypeptide derived from the HPV18 E7 protein.
Dependencies are inferred from the claim text.