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US 10,329,321 B2Granted
Site-selective functionalization of proteins using traceless affinity labels
AssigneesAlexander Krantz, Andrzej Wilczynski
InventorsAlexander Krantz, Andrzej Wilczynski
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Abstract
The present disclosure relates to site-selective labeling compounds, and methods of using such compounds.
Claims3
A compound of formula (XVII):
- wherein
- E is halogen or —SO2NHW4;
- Y is a polyalkylene oxide;
- R is azide;
- R′ is absent;
- q is 4;
- and
- W4 is a compound of formula (XV):
- wherein
- U and U′ independently are cysteine, aspartate, glutamate, 2,3-diaminopropionic acid, lysine, or ornithine;
- and
- X is histidine, 3-(4-thiazolyl)-L-alanine, (R)-2-amino-3-(thiazol-5-yl) propanoic acid or (S)-2-amino-3-(thiazol-5-yl) propanoic acid.
9 more elements
Dependencies are inferred from the claim text.