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US 10,329,315 B2Granted
Glycosphingolipids and methods of use thereof
AssigneesThe Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
InventorsDennis L. Kasper, Dingding An, Sungwhan Oh, Richard S. Blumberg, Torsten Olszak, Joana F. Neves
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Abstract
The invention provides, inter alia, immunoinhibitory glycosphingolipids and immunoinhibitory alpha-galactosylceramides and compositions and preparations thereof, and methods of use thereof including in the treatment of conditions characterized by increased iNKT cells and/or activity.
Claims18
A method comprising
- administering to a subject having or at risk of developing a condition characterized by increased invariant natural killer T (iNKT) cell numbers or activity an isolated immune inhibitory alpha-galactosylceramide in an effective amount to decrease iNKT cell numbers or activity,
- wherein the isolated alpha-galactosylceramide has the structure
- wherein m is any integer from 11 to 15, L is any integer from 0 to 2, and n+L is any integer from 13 to 17.
Dependencies are inferred from the claim text.