US 10,329,302 B2 · Bicyclic-fused heteroaryl or aryl compounds

Bicyclic-fused heteroaryl or aryl compounds

AssigneePfizer Inc.

InventorsJohn David Trzupek, Katherine Lin Lee, Mark Edward Bunnage, Seungil Han, David Hepworth, Frank Eldridge Lovering, John Paul Mathias, Nikolaos Papaioannou, Betsy Susan Pierce, Joseph Walter Strohbach, Stephen Wayne Wright, Christoph Wolfgang Zapf, Lori Krim Gavrin, Arthur Lee, David Randolph Anderson, Kevin Joseph Curran, Christoph Martin Dehnhardt, Eddine Saiah, Joel Adam Goldberg, Xiaolun Wang, Horng-Chih Huang, Richard Vargas, Michael Dennis Lowe, Akshay Patny

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Abstract

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Claims2

Dependent claims

A method of treating rheumatoid arthritis in a human comprising administering to the human in need of such treatment a therapeutically effective amount of 1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide, or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

15/862,691Filed 5 Jan 2018 · continuation

Priority

4 Apr 2014

Published

US 2018/0127432 A110 May 2018

Granted

25 Jun 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification56 codes

A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
C07D 491/056
Ortho-condensed systems: with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
A61K 31/40
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having five-membered rings with one nitrogen as the only ring hetero atom,…
A61K 31/4015
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: having oxo groups…

Family

Application61/975,473Us provisional application · filed 4 Apr 2014

Application14/678,114Parent of this continuation · filed 3 Apr 2015

Application15/232,892Parent of this continuation · filed 10 Aug 2016

US 9,458,168 B2Parent of this continuation · filed 4 Oct 2016

US 2018/0127432 A1Pre-grant publication · published 10 May 2018

US 9,879,022 B2Parent of this continuation

US 2015/0284405 A1Published application

US 2016/0347760 A1Published application

US 10,329,302 B2This patent

From the US filing history. Foreign family members aren’t listed.