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US 10,329,299 B2Granted
Heterocyclic compounds and uses thereof
AssigneeInfinity Pharmaceuticals, Inc.
InventorsAlfredo C. Castro, Catherine A. Evans, Somarajannair Janardanannair, Andre Lescarbeau, Tao Liu, Martin R. Tremblay
Life of this patent
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Abstract
Provided herein are compounds of Formula (I″) or (A″), pharmaceutical compositions comprising the compounds, and methods of use thereof. The compounds provided herein modulate kinase activity, including PI3 kinase activity, and are useful for treating diseases and conditions associated with kinase activity, including PI3 kinase activity.
Claims26
A compound of Formula (I″):
- wherein:
- R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or —COR2;
- B is hydrogen, alkyl, cycloalkyl, or aryl;
- wherein R2 is hydrogen;
- R1c is hydrogen, alkyl, alkenyl, or alkynyl;
- R2c is hydrogen, alkyl, alkenyl, or alkynyl;
- Wd is:
- wherein
- X1, X2 and X3 are each independently C, CR13, or N;
- and
- R10, R11, R12, and R13 are each independently hydrogen, unsubstituted alkyl, or amino;
- X is N;
- wherein each alkyl, alkenyl, or alkynyl is optionally substituted with one or more halo, OH, alkoxy, NH2, NH(alkyl), N(alkyl)2, C(O)H, CO(alkyl), COOH, COO(alkyl), CONH2, CONH(alkyl), CON(alkyl)2, S(O)(alkyl), S(O)2(alkyl), cycloalkyl, heterocycloalkyl, aryl or heteroaryl;
- wherein each cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more halo, alkyl, alkenyl, alkynyl, OH, alkoxy, oxo, NH2, NH(alkyl), N(alkyl)2, C(O)H, CO(alkyl), COOH, COO(alkyl), CONH2, CONH(alkyl), CON(alkyl)2, S(O)(alkyl), or S(O)2(alkyl);
- or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or mixture of stereoisomers thereof.
12 more elements
A compound, which is
- or a pharmaceutically acceptable salt, hydrate, or solvate thereof.
A compound, which is
- or a pharmaceutically acceptable salt, hydrate, or solvate thereof.
Dependencies are inferred from the claim text.