Indole derivatives
AssigneeRichter Gedeon Nyrt.
InventorsGyula Beke, János Éles, András Boros, Sándor Farkas, György Miklós Keserü
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Abstract
The present invention relates to compounds of the general form (I). The present invention relates to new substituted diazepino-indole derivatives of the general formula (I), and to pharmaceutically acceptable salts thereof, as well as to pharmaceutical compositions comprising such compounds, to new intermediate thereof, as well as to the use of such compounds in treatment or prevention of disorders associated with melanin-concentrating hormone receptor 1 activity.
Claims21
A compound of the formula (I)
- wherein
- A is CH or nitrogen;
- R is hydrogen or halogen or C1-C6 straight or branched chain alkyl group;
- R1 is hydrogen or halogen, or
- C1-C6 straight or branched chain alkyl group, or
- C1-C6 straight or branched chain alkoxy group, or
- mono- or polyhalogenated C1-C6 straight or branched chain haloalkyl group;
- R2 is hydrogen or halogen, or
- C1-C6 straight or branched chain alkyl group, or
- C1-C6 straight or branched chain alkoxy group, or
- mono- or polyhalogenated C1-C4 straight or branched chain haloalkyl group;
- R3 is hydrogen, or
- C1-C6 straight or branched chain alkyl group, optionally substituted with C3-C6 cycloalkyl group, or
- mono- or polyhalogenated C1-C6 straight or branched chain haloalkyl group, or
- C3-C6 cycloalkyl group, or
- (C1-C6 straight or branched chain alkyl)-C(O)-group;
- or salts, geometric isomers, stereoisomers, diastereomers, or hydrates thereof.
A compound of formula (II), tert-butyl 9-bromo-1H,2H,3H,4H,5H-[1,4]diazepino[1,7-a]indol-3-carboxylate,
Dependencies are inferred from the claim text.