Process for preparing a compound

A process for preparing (R)-5-bromo-4-(3-amino)piperidin-1-yl)-3-(cyclopropanecarboxamido)-1H-pyrrolo[2,3-b]pyridine of Formula (I):

• or a pharmaceutically acceptable salt thereof, comprising the step of reacting a compound of Formula (II):
• wherein X is I, Cl, or Br, with a compound of Formula (III):
• wherein R is an amino protecting group selected from the group consisting of:
• triphenylmethyl (trityl), tert-butyloxycarbonyl (Boc), carboxybenzyl (Cbz), trifluoroacetyl and acetyl,
• to provide a compound of Formula (IV):
• subjecting a compound of Formula (IV) to a nitro reduction to obtain a compound of Formula (V):
• reacting a compound of Formula (V) with a compound of Formula (VI):
• wherein Rl is selected from the group consisting of chlorine, fluorine, bromine, and OR2,
• wherein R2 is selected from the group consisting of cyclopropylcarbonyl, isobutylcarbonyl, isopropylcarbonyl, ethylcarbonyl, methylcarbonyl, 2-pyridyl, and N-succinimidyl, to obtain a compound of Formula (VII):
• removing the protecting group R in the compound of Formula (VII) to provide the compound of Formula (I), or a pharmaceutically acceptable salt thereof.