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US 10,329,283 B2Granted
G protein-coupled receptor kinase inhibitors and methods for use of the same
AssigneeThe Regents of the University of Michigan
InventorsScott D. Larsen, John J. G. Tesmer, Helen Waldschmidt, Kristoff Homan, Michael William Wilson
Life of this patent
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Abstract
Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.
Claims20
A compound of Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- G is
- n is 0, 1, or 2;
- R1 is H, C1-8alkyl, C2-8alkenyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C1-4 alkylene-aryl, C1-4 alkylene-heteroaryl, C3-8 cycloalkylene-aryl, or C3-8 cycloalkylene-heteroaryl;
- R2 is C1-8alkyl, C2-8alkenyl, C0-4alkylene-C3-8 cycloalkyl, C0-4alkylene-C3-8 cycloalkenyl, C1-4 alkylene-aryl, C1-4 alkylene-heteroaryl, C3-8 cycloalkylene-aryl, or C3-8 cycloalkylene-heteroaryl;
- R3 is H, F, Cl, CF3, CHF2, CH2F, or CH3;
- and
- R4 is H, F, or Cl.
5 more elements
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.