Back to results
US 10,329,274 B2Granted
Indole carboxamide compounds
AssigneeBristol-Myers Squibb Company
InventorsQingjie Liu, Scott Hunter Watterson, John E. Macor, Khehyong Ngu, Saleem Ahmad
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Claims14
A compound of Formula (I):
- or a salt thereof, wherein:
- X is CR4;
- A is —CHR8(pyridinyl) wherein each pyridinyl is substituted with R6 and R9;
- R1 is H, —CH3, —CF3, or phenyl substituted with zero or 1 R12;
- R2 is H, —CH3, cyclopropyl, or phenyl substituted with zero or 1 R12, provided that zero or one of R1 and R2 is phenyl substituted with zero or 1 R12;
- R3 is F, Cl, or I;
- R4 is H, F, —OH, or —OCH3;
- R6 is H, F, Cl, —CF3, or C1-3 alkoxy;
- R8 is H or C1-4 alkyl;
- R9 is —CH═CH2, —CH═CHCH2N(CH3)2, —C≡CH, or —C≡CCH3;
- and
- R12 is F, Cl, —CN, —CF3, or C1-3 alkoxy.
9 more elements
Dependencies are inferred from the claim text.